FUO Warm Slate — Design System Preview

Core Palette

Warm Linen 暖亞麻

#F5F0EB

Background

Amber 琥珀

#B45309

Primary accent

Emerald 翡翠

#059669

Success / Positive

Deep Slate 深岩

#1E293B

Primary text

Warm Stone 暖石

#78716C

Muted text

Harmony Strip

Derived Colors

Amber Hover#92400E

Amber Light#FEF3C7

Amber Muted#D97706

Emerald Hover#047857

Emerald Light#D1FAE5

Slate Light#F1F5F9

Linen Dark#E7E0D8

Deep Dark#0F172A

Semantic Colors

🔴 Fever / Alert 🟠 Warning / Pending 🟢 Resolved / Good Prognosis 🔵 Info / Reference

Callout Boxes

Key Finding

Up to 51% of FUO cases remain undiagnosed despite modern diagnostic advances.

Clinical Alert

Neutropenic FUO requires immediate empiric broad-spectrum antibiotics — do not wait for workup completion.

Positive Outcome

75% of undiagnosed classic FUO resolves spontaneously. Negative PET/CT strongly predicts remission.

Reference

2024 Delphi Consensus Panel — Open Forum Infectious Diseases (ofae298)

Hero Section

Fever of Unknown Origin

A Modern Diagnostic Approach

◆ ✦ ◆

51%

of FUO cases remain undiagnosed

Typography

Display Hero — Lora 56px 700

Fever of Unknown Origin

Section Title — Lora 40px 700

The Etiological Spectrum

Slide Title — Lora 32px 600

2024 Delphi Diagnostic Criteria

Subtitle — DM Sans 24px 500

FDG-PET/CT as an early diagnostic tool

Body Large — DM Sans 20px 400

Infections remain the most common cause of FUO worldwide, accounting for 25–50% of cases. Tuberculosis, endocarditis, and deep abscesses are consistently reported across studies.

Data Value — JetBrains Mono 28px 700

91% sensitivity | DOR 17.0

Code / Criteria — JetBrains Mono 14px 400

≥38.3°C (100.9°F) × ≥3 occasions over ≥3 weeks | ANC <500 cells/mm³

Buttons

Category Badges

Infection Inflammatory Neoplasm Miscellaneous Undiagnosed

Etiology Cards

Infections

25–50%

TB, endocarditis, abscesses, UTI. Most common cause worldwide.

Inflammatory

10–20%

Adult Still's, SLE, GCA, PMR, vasculitis.

Neoplasms

2–25%

Lymphoma (#1), leukemia, RCC. Declining with early CT detection.

Data Table

Diagnostic Tool	Sensitivity	Specificity	DOR
mNGS	91%	64%	17.0
Conventional Microbiology	34%	90%	4.7
FDG-PET/CT (positive)	84–98%	—	—

Key Takeaway

1. Verify strict 2024 Delphi criteria before labeling FUO
2. Complete mandatory workup (labs + CT chest/abd/pelvis)
3. Deploy FDG-PET/CT early when clues absent
4. Consider mNGS for culture-negative workup
5. Resist blind empiric treatment in stable patients

💡 Negative workup = good prognosis (75% spontaneous resolution)

Complete Color Reference

Color	Hex	Tier	Role
Warm Linen	#F5F0EB	Core	Background
Amber	#B45309	Core	Primary accent
Emerald	#059669	Core	Success / Positive
Deep Slate	#1E293B	Core	Primary text
Warm Stone	#78716C	Core	Muted text
Amber Hover	#92400E	Derived	Hover state
Amber Light	#FEF3C7	Derived	Badge / highlight bg
Emerald Light	#D1FAE5	Derived	Positive badge bg
Linen Dark	#E7E0D8	Derived	Border / divider
Deep Dark	#0F172A	Derived	Dark section bg
Clinical Red	#DC2626	Semantic	Fever / Alert
Clinical Blue	#2563EB	Semantic	Info / Reference